TRIMERO Diagnostics offers IVD CE marked Beta-2 Microglobulin (β2m) serum and urine assays for IMMAGE® series nephelometers.
The assays, for serum and urine samples, have been developed specifically for the Beckman Coulter’s IMMAGE® and IMMAGE® 800 Immunochemical Systems, using UDR particle-enhanced reagents.
In order to ensure lot to lot traceability, assays have been standardized to the to the 1st International Standard for Beta2 Microglobulin (code: B2M) of the WHO (World Health Organisation).
B2-microglobulin turbidimetric assays are also available for the most popular clinical chemistry analysers, for both urine and serum samples.
Other available assays for IMMAGE® nephelometers and turbidimetry include: KLoneus® Free Light Chains (FLC), Serum Amyloid A (SAA), IgD Immunoglobulins, Retinol Binding Protein (RBP) for serum and urine, Soluble Transferrin Receptor (sTfR), Hemopexin, Cystatin-C for serum and urine, A1-Microglobulin, Kappa and Lambda Light Chains for serum and urine, Complement C1q, Complement C5, Factor B (C3 Proactivator), C1 (Esterase) Inhibitor.
Read more

Greiner Bio-One, a division of Greiner AG specializing in the development, production and distribution of high-quality plastic laboratory products, is proud to announce that it has changed its logo on its website and on all its existing social media channels.
The new logos of all Greiner divisions were presented in September 2018 at the 150-years-anniversary gala in Kremsmünster (Austria) where the company is headquartered. The new Greiner Bio-One logo was developed with the aim of presenting Greiner AG visually more strongly as a group, without restricting the visual and perceived independence and autonomy of the divisions. Since this change is very time-consuming and many areas and content types are affected, it will take place in several stages over a period of up to five years. www.gbo.com
Read more

The Ziath range of CryzoTraq™ 2D-barcoded cryogenic tubes set a new standard for cryogenic storage of biological specimens at temperatures as low as -196°C.
Worldwide biobanks and biorepositories support many types of life science research including Genomics and Personalized Medicine. To ensure the integrity and viability of specimens stored in these sample storage facilities over long periods of time, the specimens are placed in a sterile storage tubes and immersed in vapor phase Liquid Nitrogen. Leak-free cryogenic tubes are therefore of utmost importance to ensure sample integrity. Produced using an innovative 2-stage injection moulding process the caps on CryzoTraq tubes deliver outstanding leak resistance. This high integrity closure on CryzoTraq tubes ensures that the sample cannot leak out and conversely that no contaminants can enter the tube. This is vitally important because if the specimen is contaminated, it is rendered useless for further research.
To ensure full sample traceability, all CryzoTraq tubes have a 2D datamatrix barcode inserted in the base of the tube. The insert is secured in place by the use of ultrasound to weld it into place. During this manufacturing process, a linear barcode is printed onto the side of the tube first, and the 2D code is automatically generated from the linear barcode therefore ensuring the two barcodes will always be the same with no errors.
Available in 2 ml and 5 ml volumes, CryzoTraq tubes are certified free from DNA, DNase, RNase, pyrogens and ATP. Each lot is sterilized with electron beam radiation. CryzoTraq tubes are manufactured from medical grade polypropylene and the caps from medical grade polyethylene.
To enable fast and precise decoding of the 2D-barcodes on CryzoTraq tubes, Ziath offers its high performance DataPaq™ Multirack and Cube scanners.
For more information, visit: www.ziath.com/index.php/products/tubes/ cryzotraq-tubes-and-racks
Read more

Provides high efficiency, saves space and enables multi-sample processing /
Customer- and application-specific solution /
Time-saving by simplified, fast operation
Shimadzu, one of the world leaders in analytical instrumentation, has announced the release of its new Nexera Prep Series Preparative Purification Liquid Chromatograph (LC). “Preparative HPLC” is a process in which specific substances are separated and purified from samples. The new Nexera Prep Series provides better prep processes for extraction of functional and impurity components, as well as purification of target compounds in the pharmaceutical, chemical and food industries. This product dramatically improves productivity via flexible scalability and an efficient, user friendly preparative workflow.
Customer- and application-specific solution
The Nexera Prep Series consists of multiple related products with the LC units as the core. Users select a pump, autosampler and detector to build a system according to the purpose of the preparative work. Systems can be configured using related products such as the LH-40 Liquid Handler, FRC-40 Fraction Collector, Shim-pack Scepter LC Column for Analysis and Preparative Work, and Column Hub.
Preparative purification is generally performed following a multi-step workflow, which requires experience and time:

1. Selection of system configuration and preparative column size based on the amount

of purified sample or injection volume required

2. Selection of fraction collector and container size according to the intended purpose
3. Investigation of separation conditions in analytical scale
4. Optimization of preparative LC conditions
5. Confirmation of the purity of collected fractions

In addition to these steps, in some cases salts need to be removed or solvent needs to be evaporated after purification, requiring additional time and effort.
Time-saving by simplified, fast operation
The Nexera Prep Series reduces the time spent on examining conditions using the software’s fractionation simulation function. It also enables simplified, fast operation in transition from analytical to preparative scale, with a column portfolio that covers a wide range of sizes. Furthermore, Shimadzu’s unique UFPLC (Ultra Fast Preparative and Purification LC) high-purity purification system reduces the time required for powderization via the elution of desalted target components with an organic solvent. This product satisfies a number of user demands, such as efficient desalting and powderization, multi-sample and multi-fraction analysis, effective separation at low cost and the ability to check the purity.
Specifically, the product can be used for the following purposes:

• Concentration and purification of immunosuppressive agents
• Preparative work for impurities in degradants of medicinal agents
• Separation and purification of functional components from natural materials
• Consecutive analysis to separate and purify polymers and their additives and confirm the purity

The Nexera Prep Purification LC System provides new features to simplify the preparative workflow:

1. Reduces the time required for investigating conditions
   With the fractionation simulation function of the LabSolutions analysis software and the Shim-pack Scepter LC column for analytical and preparative HPLC, which offers excellent scalability, the product reduces the time required for investigating preparative work conditions. The LH-40 Liquid Handler can be used both, as a fraction collector and as an autosampler for large-volume injection with liquid surface detection function (option). It also enables seamless purity checks through re-injection (option) of collected sample after fractionation. Additional features including a sample rescue protocol to collect the sample from the system if an error occurs after an injection, a function to automatically extract the target peaks only, and high-purity preparative purification using detector signals from up to four channels, enable more efficient operation.
2. UFPLC high-purity purification system
   Samples must be in a state of concentrated solution or dry powder to analyze their structure or to store them. When a solution contains water, it takes time to dry and concentrate it. When a salt such as trifluoroacetate has been added, it remains in the crystal of the compound, lowering the purity and negatively influencing pharmacokinetic studies and other tests. Shimadzu’s unique, automated UFPLC purification system introduces fractions containing the target compound, separated in a preparative column, into a trap column. Salt and water are then washed off and elution is induced with an organic solvent. This reduces the time required for drying, providing compounds with a high level of purity.
3. Flexible system scalability
   Both the LH-40 Liquid Handler and FRC-40 Fraction Collector are designed to save installation space, requiring only half the space of other vendors’ products. They support containers of a form and size suitable for the recovered quantity. Up to six units can be connected, so up to 3240 10 mm diameter test tubes can be placed. Using the new Column Hub, up to six columns and four flow-line switching valves can be installed, enabling the compact configuration of various systems.

Web summary
Shimadzu has announced the release of its new Nexera Prep Series Preparative Purification Liquid Chromatograph (LC). It provides better prep processes for extraction of target compounds and impurities during drug discovery in the pharmaceutical industry and purification of functional components in the chemical and food industries. This product improves productivity dramatically via efficient preparative workflows using LC or LC-MS methodology.
Web link: www.shimadzu.eu/nexera-prep
Read more

Novodiag is an innovative molecular diagnostics solution for the detection of multiple or targeted pathogens in clinical samples. Combining qPCR and microarray technologies in a single-use cartridge containing all the necessary reagents, the Novodiag system allows an extremely simplified analysis process with minimal preparation time and results in approximately 1 hour. The latest addition to the tests already available includes detection of Clostridium difficile (Novodiag C.difficile), identification of bacteria responsible for gastrointestinal infections (Novodiag Bacterial GE+) and screening of more than 200 variants of most common CPE and colistin-resistance markers (Novodiag CarbaR+). Two new tests will be launched this year: one for the detection of parasites in stool with the identification of more than twenty targets (protozoa including microsporidia and helminths) and another for the diagnosis of meningitis. The complete system comprises the Novodiag instrument, touchscreen computer, barcode scanner, Novodiag software and Novodiag cartridge.

MOBIDIAG
Read more