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Author Archive for: 3wmedia
Entries by 3wmedia
Is it a urinary tract infection?
Whilst the respiratory tract is the most frequent site of infection, in the developed world the urinary tract is the second most frequent site; 50% of otherwise healthy women will experience at least one UTI. The shortness of the female urethra and its proximity to both vagina and anus in women contribute to the much […]
Clinical utility of PIVKA-II in the diagnosis of hepatocellular carcinoma
The need for cost-effective and reliable early diagnostic tools for hepatocellular carcinoma (HCC) is more than ever of great interest, as incidence rates are on the rise globally and two thirds of the patients are diagnosed with HCC in advanced stages. Alpha-fetoprotein (AFP), the marker that is currently in widespread use for HCC, lacks sensitivity […]
Improving diagnosis of Zika virus infection: an urgent task for pregnant women
Mosquito-borne Zika virus (ZIKV) was the cause of the recent large outbreak of Zika disease in America. Despite fever, Zika is a mild disease, although epidemics in recent years have demonstrated an association with the appearance of severe congenital malformations (microcephaly). Owing to ZIKV serology cross-reactivity with other tropical flaviviruses, the final diagnosis relies on […]
Simple, fast and highly sensitive colorimetric detection of Zika virus
Zika virus (ZIKV) has recently emerged as a global threat, but current diagnostic techniques are cumbersome and time-consuming. We developed a simple, fast and highly sensitive ZIKV molecular detection method. Within 35 min, we could detect even a single copy of ZIKV RNA by merely observing a colorimetric signal with the naked eye. by Dohwan […]
Point-of-care molecular test for Zika infection
The recent outbreak of Zika virus (ZIKV) infection has led to a serious threat to public health. Rapid and sensitive diagnostics for ZIKV infection are crucial because Zika infection is usually mild and often asymptomatic, but may have serious consequences to infants born to infected mothers. We report on a simple, sensitive, inexpensive, point-of-care diagnostic […]
Complete laboratory diagnosis of Zika virus infections
Laboratory diagnosis of Zika virus (ZIKV) infections is based on two main pillars: direct detection of the viral RNA genome and serological detection of anti-ZIKV antibodies. Direct detection of the virus by reverse transcriptase real-time polymerase chain reaction (RT real-time PCR) is the most important method for diagnosing early acute infections. A new RT real-time […]
Quality control testing on a random access molecular diagnostics platform running quantitative viral load assays
The DxN VERIS Molecular Diagnostics System* from Beckman Coulter is a real-time PCR analyser for accurate and precise quantitative detection of both RNA and DNA targets. Single sample random access offers workflow flexibility and automation benefits to the laboratory. The design features of the DxN VERIS System and performance characteristics of the VERIS HCV, HIV-1, […]